TzKal-Zuk
The arena is square shaped, and there are three pillars in it. These pillars can be used to safespot monsters, although they do not offer complete protection from all the monsters in the cave considering their spawns are spread whenever a new wave starts. In addition, every wave until 67 spawns three or six nibblers, which attempt to destroy the pillars.
The general idea is to neutralise the nibblers at the start of each wave, preferably with Ice Barrage, and find a way to manoeuvre the arena to trap monsters behind the pillars to minimise the damage; attempting to purely tank will almost certainly lead to death in the later waves. All monsters are very accurate and deal high damage, but each one's attacks (apart from Zuk's) can be fully blocked with protection prayers.
Guide, gear, inventory, locations, pictures and money making rates from the OSRS Wiki (CC BY-NC-SA 3.0).